Translational research methods for diabetes, obesity and cardiometabolic drug development : a focus on early phase clinical studies / edited by Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch.
Tipo de material:
TextoEditor: London : Springer London : Springer, 2015Descripción: xii, 312 páginas : 76 ilustraciones, 39 ilustraciones en colorTipo de contenido: - texto
- computadora
- recurso en línea
- 9781447149200
- R1
Contenidos:
1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs.
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1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs.
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