Somatic Cell Nuclear Transfer / edited by Peter Sutovsky.

Springer eBooks

Nuclear Remodeling and Nuclear Reprogramming for Making Transgenic Pigs by Nuclear Transfer -- Somatic Cell Nuclei in Cloning -- Cloning Cattle -- Centrosome Inheritance after Fertilization and Nuclear Transfer in Mammals -- Developmental, Behavioral, and Physiological Phenotype of Cloned Mice -- Nudeolar Remodeling in Nuclear Transfer Embryos -- Somatic Cell Nuclear Transfer (SCNT) in Mammals -- Mitochondrial DNA Inheritance after SCNT -- Activation of Fertilized and Nuclear Transfer Eggs.

Topics discussed include recent progress in pig SCNT and production of transgenic and knock out pigs for biomedical research and xenotransplantation, cattle cloning, behavioral studies in cloned mice, nuclear remodeling and imprinting, cell cycle regulation, nucleolar biogenesis, the effect of artificial activation on early development of cloned embryos, and inheritance of mitochondrial DNA and centrosome. Altogether, the present tome provides the reader with a unique developmental, molecular and cell biological view of the exciting SCNT technology, while also discussing its pitfalls and possible future directions and detours. Somatic Cell Nuclear Transfer will help both students and experienced researchers to further develop their knowledge and understanding of mammalian embryonic development.

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