Semaphorins: Receptor and Intracellular Signaling Mechanisms / edited by R. J. Pasterkamp.

Springer eBooks

The CRMP Family of Proteins and Their Role in Sema3A Signaling -- GTPases in Semaphorin Signaling -- Intracellular Kinases in Semaphorin Signaling -- MICAL Flavoprotein Monooxygenases: Structure, Function and Role in Semaphorin Signaling -- Signaling of Secreted Semaphorins in Growth Cone Steering -- Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules -- Proteoglycans as Modulators of Axon Guidance Cue Function -- Semaphorin Signals in Cell Adhesion and Cell Migration: Functional Role and Molecular Mechanisms -- Semaphorin Signaling During Cardiac Development -- Semaphorin Signaling in Vascular and Tumor Biology -- Semaphorin Signaling in the Immune System.

The book summarizes our progress in understanding the receptor and intracellular signaling mechanisms utilized by a family of proteins called the semaphorins. Originally these protein were identified as "axon guidance cues" important for the formation of nerve tracts but now it is realized that semaphorins subserve several distinct functions in a multitude of organ systems. The purpose of this book is to summarize our knowledge and make it available as a useful and comprehensive tool for the scientific community. This book will both be interesting for people working in the field as well as colleagues that work in other fields of science and would like to learn more about semaphorins and associated signaling mechanisms. All the latest techniques and results are summarized in this book which covers the entire semaphorin field from neurosciences to cardiovascular research and beyond. The strength of this book is that it gives a very comprehensive overview of all our knowledge of semaphorin biology and signaling and allows one to compare semaphorin functions between different biological systems.

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