Problems of High Altitude Medicine and Biology / edited by Almaz Aldashev, Robert Naeije.

Springer eBooks

Introduction: 45 Years Of Mountain Medicine -- High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases -- The Cellular Effects Of Hypoxia In The Pulmonary Circulation -- Angiogenesis And Chronic Hypoxic Pulmonary Hypertension -- Tetrahydrobiopterin And Pulmonary Hypertension -- Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53 -- Pulmonary Adaptation To High Altitude In Wild Mammals -- The Lung At High Altitude: Between Physiology And Pathology -- Sildenafil And Hypoxic Pulmonary Hypertension -- The Role Of Antioxidants In Modulation Of Acclimatization Processes -- Gene Polymorphisms And High Altitude Pulmonary Hypertension -- Genetic Factors In The Acute Response To Hypoxia In Animals Models -- Who Gets High Altitude Pulmonary Edema And Why? -- Effects Of Inhaled Nitric Oxide And Oxygen In High Altitude Pulmonary Edema -- Altered Autoregulation Of Cerebral Blood Flow In Hypoxia: Relevance To The Pathophysiology Of Acute Mountain Sickness -- Cardiac Limitation To Exercise Capacity At High Altitudes -- Pediatric High Altitude Heart Disease: A Hypoxic Pulmonary Hypertension Syndrome -- Clinical And Functional Features Of Chronic Obstructive Pulmonary Disease In The Highlanders Of Kyrgzstan -- Monitoring The Morphological And Functional Parameters Of Platelets In Patients With Thrombocytopenic Purpura During High Mountain Treatment -- Role Of Exogenous Hypoxia In Treatment Of Chronic Glomerulonephritis -- Atherogenesis Of Brain Vessels In Conditions Of Hypoxia In Kyrgyz Highlanders -- Particularities Of Neuropsychotropic Effects Of Mexidol In Various Altitude Conditions -- Influence Of High-Altitude Hypoxia On Adaptive And Non-Adaptive Structural Changes In The Vessels Of The Pulmonary Circulation -- Acute Oxygen Sensing Mechanisms.

This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake of Issyk-Kul, in Kyrghyzstan, in June 5-6, 2006. It was a surprise for several European and North and South-American scientists to discover the still on-going momentum high level altitude physiology research, which was extremely active but insufficiently acknowledged in this remote Central Asian country at the time of the USSR. Accordingly, the setting was perfect for numerous positive scientific interactions, exchanges of ideas, and structuring of new international collaborations. Overall, the meeting was an ideal mix of cell biology, integrative physiology and medical applications. Hypoxia is and remains a major public health issue in many populated mountainous areas all over the world. We are sure that this book will be become a long-lasting essential reference.

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