Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders : Novel Strategies for Research and Treatment / edited by Michael S. Ritsner, Abraham Weizman.

Springer eBooks

Neuroactive Steroids and Brain Functions -- Neurosteroid: Molecular Mechanisms of Action on the GABAA Receptor -- Steroid Metabolism in Glial Cells -- Involvement of Neuroactive Steroids in Hippocampal Disorders: Lessons from Animal Models -- Estrogen Modulation of Visceral Nociception -- Neuroactive Steroids: Effects on Cognitive Functions -- Estrogen, Cholinergic System and Cognition -- Local Production of Estrogen and its Rapid Modulatory Action on Synaptic Plasticity -- Effects of Estradiol and DHEA on Morphological Synaptic Plasticity -- Pregnane Steroids and Short-Term Neural Plasticity -- Steroidogenesis and Neuroplasticity in the Songbird Brain -- Dehydroepiandrosterone, as Endogenous Inhibitor of Neuronal Cell Apoptosis: Potential Therapeutic Implications in Neurodegenerative Diseases -- DHEA and DHEA-S, and their Functions in the Brain and Adrenal Medulla -- Neurosteroids in the Aging Brain -- Neuroactive Steroids and Neuropsychiatric Disorders -- Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia -- Neurosteroids in Cortical Development and the Etiology of Schizophrenia -- Neurosteroid Perturbation and Neuropsychiatric Symptoms in Schizophrenia: From the Mechanisms to the Treatment -- Dehydroepiandrosterone Administration in Treating Medical and Neuropsychiatric Disorders -- Allopregnanolone and Pregnenolone Alterations Following Pharmacological Agents in Rodents and Clinic Populations -- Reconsidering Classifi cations of Depression Syndromes: Lessons from Neuroactive Steroids and Evolutionary Sciences -- Neuroactive Steroids in Brain and Relevance to Mood -- The Role of Neuroactive Steroids in Anxiety Disorders -- The Role of Midbrain 3?,5?-THP in Mediating Exploration, Anxiety, Social, and Reproductive Behavior -- The Role of Progesterone and its Metabolites in Premenstrual Disorders of Affect -- Neurosteroid Derangement in Women Diagnosed with Eating Disorders -- Neurosteroids in Alcohol and Substance Use -- The Role of Neurosteroids in Development of Pediatric Psychopathology.

This book provides a comprehensive and up-to-date overview of the role of neurosteroids and neuroactive steroids, such as pregnenolone and dehydroepiandrosterone, allopregnanolone, progesterone and others in the regulation of brain processes and neuropsychiatric disorders. The book addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain including the aging brain, cognitive functioning, response to stress, anxiety and mood disorders, schizophrenia, and Alzheimer's disease. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors are known experts who suggest that neuroactive steroids could have a role in clinical practice. This book offers a comprehensive, state-of-the-art review of these important bioactive molecules that is relevant to a broad readership which includes neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, graduate students in neuroscience, and health care providers in the field of mental health and neurology.

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