It's Great! Oops, No It Isn't : Why Clinical Research Can't Guarantee the Right Medical Answers / by Ronald R. Gauch.

Springer eBooks

Medical Research Explained -- Medical Research – Searching for Answers -- The Case-Control Method – Looking Backwards -- The Cohort Study – Watchful Waiting -- The Clinical Trial –The Gold Standard -- Comparing the Methods – Qualitative Differences -- Understanding the Clinical Trial -- The Protocol – The Guiding Light -- The Control Group – Leveling the Playing Field -- Measurements – They'ever Exact -- Bias Control – A Closer Look at Blinding and Randomization -- Utility – Are Clinical Trial Results Useful? -- Research Discrimination – Inadequately Tested Populations -- Seven Deadly Flaws – The Clinical Trials' Achilles' Heel -- Tools of the Trade -- Statistics – Was the Finding Significant? -- Analysis Issues – A Lot of Choices -- Meta Analysis – An Alternative to Large Trials -- The Real World -- Research Results That Clashed – What's the Right Answer? -- Hormone Replacement Therapy – The Silver Bullet That Misfired -- Publishing – Getting the Word Out to Doctors -- The Public Forum – Sharing the News with the Public -- Product Development – Getting Discoveries to the Market -- Medical Innovations – Regulators, Resources and Results -- Science and Politics – A Troubling Mixture -- Research Misconduct – Irresistible Temptation -- Postmarketing Surveillance – An Imperfect System -- Regulatory Reform – Changes Needed -- Journey's End – A Call for Action.

This book dissects medical research methodology and through a penetrating inquiry into its triumphs and tragedies explains why correct answers are so hard to achieve. What emerges from this inquiry is the unexpected and stunning conclusion that medical researchers can never be sure that they’ve ended up with a truthful answer. In It’s Great! readers learn why the quest for knowledge through clinical trials is fraught with problems that even the best researchers cannot overcome. A fascinating gallery of cases illustrates the perils investigators face. Particular emphasis is given to the “clinical trial”, the so-called gold standard for medical research, and its seven fatal flaws show succinctly why getting the right research answer is so problematic. In example after example, the author challenges the notion that medical research is too complex for the average citizen to comprehend. Understanding the imperfect world of clinical research allows the reader to step up and begin to ask his or her own questions, to challenge conclusions, to have doubts and not be afraid to raise them. People who care about their health and the health of others should not be innocent bystanders; they have a right, maybe even an obligation to become involved. After all, it’s their health that is at stake.

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