Systems Biology in Biotech & Pharma : A Changing Paradigm / by Aleš Prokop, Seth Michelson.
Tipo de material:
TextoSeries SpringerBriefs in Pharmaceutical Science & Drug Development ; 2Editor: Dordrecht : Springer Netherlands, 2012Descripción: xviii, 127 páginas 16 ilustraciones en color. recurso en líneaTipo de contenido: - texto
- computadora
- recurso en línea
- 9789400728493
- R-RZ
Springer eBooks
Abstract -- 1 Introduction: Discovery & Development - New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review -- 2 Discovery: Use Of Systems Biology For Identifying Targets -- 3 Integrative Systems Biology I - Biochemistry: Phase I Lead Discovery & Molecular Interactions -- 4 Integrative Systems Biology Ii - Molecular Biology: Phase 2 Lead Discovery & In Silico Screening -- 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I -- 6 Development: In Vivo Pharmacology - Systems Biology In Health & Disease Ii -- 7 Development: Pharmacokinetics – Systems Biology In Health & Disease Iii -- 8 Development: Multiscale Csb – Simulation Tools -- 9 Development: Drug Formulation & Delivery -- 10 Development: Preclinical Model Based Drug Development -- 11 Systems Biology: Impact On Pharma And Biotech -- 12 Acknowledgment -- 13 Bibliography.
Systems Biology (SB) is a suite of technologies and methodologies that resulted, conceptually from the merging of two basic paradigms, reductionism and holism. It represents a combination of reductionist and holistic approaches to the relationships among the elements of a system, with the goal of identifying its emergent properties and defining, quantitatively, molecular, cellular, tissue, organ and whole body processes. One manifestation of SB is as a tool for hypothesis generation about a system that is typically too large and complex to understand by simple reasoning.
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