Blood pressure and arterial wall mechanics in cardiovascular diseases / edited by Michel E. Safar, Michael F. O'Rourke, Edward D. Frohlich.

Springer eBooks

SECTION I - Basic concepts and pathophysiological mechanisms of PAH -- Principles and definitions of arterial stiffness, wave reflections and pulse pressure amplification -- Large arteries, microcirculation and the mechanism of hypertension -- Direct measurement of local arterial stiffness and pulse pressure -- Determination of systemic and regional arterial stiffness -- Calcifications -- Mechanical stress and the arterial wall -- Pulsatile stress, arterial stiffness and endothelial function -- Endothelial-dependent vascular modulation by pulse perfusion -- Central arterial aging: humans to molecules -- Elastin, calcium and the arterial wall -- Animals models for studies of arterial stiffness -- Renin-angiotensin system, large arteries and microcirculation -- Arterial distensibility and the sympathetic nervous system -- SECTION II - Clinical aspects and end-organ damage in PAH -- Brachial and central pulse pressure, and cardiovascular risk -- Large artery stiffness and cardiovascular risk: Introduction to risk assessment and new strategies -- Therapeutic trials and cardiovascular risk -- Genetic aspects of arterial stiffness and pulse pressure in clinical hypertension -- Heart rate, pulse pressure and arterial stiffness -- The relation of large arterial structure and function to cardiac hypertrophy in hypertension -- Arterial stiffness in hypertension and chronic heart failure -- Arterial stiffness and various cardiovascular diseases -- Arterial function in end-stage renal disease -- Arterial changes in renal transplantation -- Carotid cerebral circulation and arterial stiffness -- Aging process -- Hypertension in women: is it different? -- Arterial stiffness and wave reflections at the different stages of the hypertensive vascular disease -- Diabetes, (lipids) and other cardiovascular risk factors -- Pulsatile hemodynamics and thrombino formation -- Lipids and atherosclerotic disease -- SECTION III - Clinical pharmacology and therapeutics of PAH -- Antihypertensive drug treatment and cardiovascular prevention: an update including the 2003-2004 secondary prevention trials -- Changing concepts on the role of blood pressure reduction in cardiovascular prevention -- Principles of measurement, preventing and treating arterial stiffness -- Nitrates and endothelial function -- De-stiffening strategy, sodium balance and blockade of the renin-angiotensin system -- Aldosterone antagonists, arterial stiffness and wave reflections -- Drugs acting on collagen cross-linking -- Long-term effects of converting enzyme inhibitors, calcium antagonists and ?-blocking agents on peripheral and central arteries -- Statins and arterial stiffness -- Nonpharmacological treatment of increased arterial stiffness and altered wave reflections -- BP variability.

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