Cancer biology and the nuclear envelope : recent advances may elucidate past paradoxes / edited by Eric C. Schirmer, Jose I. de las Heras.

Springer eBooks

Section I: History and use of the nuclear envelope in cancer prognosis: Overview and perspective -- Cancer and the nuclear envelope, a history and perspective -- The role of the nuclear lamina in cancer and apoptosis -- The diagnostic pathology of the nuclear envelope in human cancers -- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer -- "To be or not to be in good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer -- Section II: The nuclear envelope in cell cycle regulation and signaling -- pRb and lamins in cell cycle regulation and aging -- Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology -- NETs and cell cycle regulation -- Nuclear envelope regulation of signaling cascades -- Section III: Nuclear envelope regulation of the genome -- Nuclear envelope - connecting structural genome organization to regulation of gene expression -- Studying lamins in invertebrate models -- Lamin organization of chromosome positioning -- Section IV: Functions of the NPC in cancer -- NPC proteins linked in cancer overview -- Roles of the nucleoporin Tpr in cancer and aging.- Ran GTPase in nuclear envelope formation and cancer metastasis -- Wnt signaling proteins associate with the nuclear pore complex: implications for cancer -- Section V: The nuclear envelope in DNA damage and stress responses -- DNA damage and lamins -- Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression -- Lamines and oxygen stress damage in cell proliferation.- Section VI: The nuclear envelope link to cell migration and metastasis -- Nuclear mechanics in cancer -- Nuclear envelope in nuclear positioning and cell migration -- Nesprins in cell stability and migration -- Connecting the nucleus to the cytoskeleton for nuclear positioning and call migration -- Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope -- Nuclear envelope invaginations and cancer -- Mechanisms of nuclear size regulation in model systems and cancer -- Control of nuclear size by NPC proteins -- Do lamins influence disease progression in cancer?.   .

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