The smoothened receptor in cancer and regenerative medicine / edited by Martial Ruat.
Tipo de material:
TextoSeries Topics in Medicinal Chemistry ; 16Editor: Cham : Springer International Publishing : Springer, 2015Descripción: vii, 210 páginasTipo de contenido: - texto
- computadora
- recurso en línea
- 9783319197555
- RS400-431
Contenidos:
Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
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Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
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