Mutant p53 and mdm2 in cancer / edited by Swati Palit Deb, Sumitra Deb.

Springer eBooks

p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer -- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis -- p53 mutation in the genesis of metastasis -- Structural studies on mechanisms to activate mutant p53 -- Mutant p53 and the response to chemotherapy and radiation -- The p53-MDM2 loop: a critical juncture of stress response -- Mechanisms of mutant p53 stabilization in cancer -- Crosstalk between Mdm2, p53 and HIF-1?: distinct responses to oxygen stress and implications for tumour hypoxia -- MDM2 overexpression, activation of signaling networks, and cell proliferation -- p53-independent effects of MDM2 -- Splice variants of MDM2 in oncogenesis -- MDM2 and MDMX involvement in human cancer -- Targeting the p53-MDM2- MDMX loop for cancer therapy -- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ) -- The role of tumor suppressor p53 in the antioxidant defense and metabolism -- Lung cancer stem cells, p53 mutations and MDM2.

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