The smoothened receptor in cancer and regenerative medicine / 
edited by Martial Ruat. 
 - vii, 210 páginas : 
 - Topics in Medicinal Chemistry,  16  1862-2461 ; .
<br/><br/> Springer eBooks 
<br/><br/>Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure. 
<br/><br/><label>ISBN: </label>9783319197555 
<br/><br/><label>LC Class. No.: </label>RS400-431