Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS / edited by Santokh Gill, Olga Pulido.

Springer eBooks

General Concepts -- Glutamate Receptors in Peripheral Tissues: Distribution and Implications for Toxicology -- Glutamate Receptor Pharmacology: Lessons Learned from the Last Decade of Stroke Trials -- Expression of Non-Organelle Glutamate Transporters to Support Peripheral Tissue Function -- Anticancer Effects of Glutamate Antagonists -- Glutamate Receptors and their Role in Acute and Inflammatory Pain -- Specific Target Tissues, Organs, and Systems -- The Vertebrate Retina -- Glutamate Receptors in Taste Receptor Cells -- Glutamate Receptors in Endocrine Tissues -- Adrenal Glutamate Receptors: A Role in Stress and Drug Addiction? -- Glutamate Receptors in the Stomach and their Implications -- Glutamate Toxicity in Lung and Airway Disease -- Glutamate: Teaching Old Bones New Tricks—Implications for Skeletal Biology -- Expression and Function of Metabotropic Glutamate Receptors in Liver -- Neuroexcitatory Signaling in Immune Tissues -- Platelet Glutamate Receptors as a Window into Psychiatric Disorders -- Non-Mammalian Organisms -- Analysis of Glutamate Receptor Genes in Plants: Progress and Prospects.

When the brain suffers an injury such as a stroke, neurons release glutamate onto nearby neurons which become excited, overloaded with calcium, and die. Normal neurotransmission is altered during injury, causing excess calcium to activate enzymes which eventually leads to destruction of the cell. This damage occurs through glutamate receptors. At one time, glutamate receptors were thought to exist exclusively in the CNS. It is only recently that they have been found outside the CNS, in the peripheral tissue. The editors of Glutamate Receptors in Peripheral Tissue: Excitatory Transmission Outside the CNS are the first to show their presence outside the CNS using molecular biology techniques and immunohistochemistry. This text is the first devoted exclusively to these receptors in peripheral tissues.

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