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Toll and Toll-Like Receptors: An Immunologic Perspective / by Tina Rich.

Por: Colaborador(es): Tipo de material: TextoTextoSeries Molecular Biology Intelligence UnitEditor: Boston, MA : Springer US, 2005Descripción: X, 218 páginas, recurso en líneaTipo de contenido:
  • texto
Tipo de medio:
  • computadora
Tipo de portador:
  • recurso en línea
ISBN:
  • 9780387274454
Formatos físicos adicionales: Edición impresa:: Sin títuloClasificación LoC:
  • QH573-671
Recursos en línea:
Contenidos:
The Function of Toll-Like Receptors -- Structures and Motifs Involved in Toll Signaling -- “Supramolecular” Activation Clusters in Innate Immunity -- Interleukin-1 Receptor/Toll-Like Receptor Signaling -- Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response -- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling -- Pathogen Avoidance Using Toll Signaling in C. elegans -- Forward Genetic Analysis of TLR Pathways -- Agonists of Toll-Like Receptor 9.
Resumen: Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these ‘higher’ immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self – non-self recognition.
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Springer eBooks

The Function of Toll-Like Receptors -- Structures and Motifs Involved in Toll Signaling -- “Supramolecular” Activation Clusters in Innate Immunity -- Interleukin-1 Receptor/Toll-Like Receptor Signaling -- Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response -- The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling -- Pathogen Avoidance Using Toll Signaling in C. elegans -- Forward Genetic Analysis of TLR Pathways -- Agonists of Toll-Like Receptor 9.

Until recently innate immunity was viewed as the poorer relative of the sophisticated adaptive immune response. We now know, however, that these ‘higher’ immune responses are actually underpinned by an elegantly hewn system of innate immune surveillance. Discovered first by developmental biologists, again by immunologists, and even by sociologists, Toll receptors have revolutionized our understanding of innate immunology. Although a small part of a complex system, Toll receptor biology compels us to revisit existing models of self – non-self recognition.

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