Voltage-Gated Calcium Channels / by Gerald W. Zamponi.

Springer eBooks

Ca2+ Chemistry, Storage and Transport in Biologic Systems -- Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators -- A Brief History of Calcium Channel Discovery -- Biochemical Studies of Voltage-Gated Ca2+ Channels -- Molecular Properties of Voltage-Gated Calcium Channels -- Role of ? Subunits in Voltage-Gated Calcium Channel Functions -- Distribution and Targeting Mechanisms of Voltage Activated Ca2+ Channels -- The Calcium Channel and the Transmitter Release Site -- Determinants of G Protein Inhibition of Presynaptic Calcium Channels -- Phosphorylation-Dependent Regulation of Voltage-Gated Ca2+ Channels -- Ca2+-Dependent Modulation of Voltage-Gated Ca2+ Channels -- Voltage-Dependent Inactivation of Voltage Gated Calcium Channels -- Selective Permeability of Voltage-Gated Calcium Channels -- The Run-Down Phenomenon of Ca2+ Channels -- Calcium Channels As Therapeutic Targets -- Calcium Channelopathies -- The Molecular Basis of Ca2+ Antagonist Drug Action-Recent Developments -- Calcium Channel Block and Inactivation -- Block of Voltage-Gated Calcium Channels by Peptide Toxins -- Calcium Channels in the Heart -- Post-Genomic Insights into T-Type Calcium Channel Functions in Neurons -- Voltage-Gated Ca2+ Channels of the Vertebrate Retina -- Exploring the Function and Pharmacotherapeutic of Potential Voltage-Gated Ca2+ Channels with Gene-Knockout Models.

Voltage Gated Calcium Channels is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area, taking into account the most recent literature and concepts. This is the only all-encompassing calcium channel book currently available, and is an essential resource for academic researchers at all levels in the areas neuroscience, biophysics, and cardiovascular sciences, as well as to researchers in the drug discovery area.

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