The Chemokine Receptors / edited by Jeffrey K. Harrison, Nicholas W. Lukacs.

Springer eBooks

The Birth and Maturation of Chemokines and Their Receptors -- The Structural Biology of Chemokines -- Chemokine Receptors: A Structural Overview -- Chemokine Signaling in T-Lymphocyte Migration: The Role of Phosphoinositide 3-kinase -- Chemokine Receptors and Neutrophil Trafficking -- Chemokine Receptors and Dendritic Cell Trafficking -- Chemokine Receptors and Lymphocyte Trafficking -- Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis -- Chemokines in Transplantation Biology -- The Chemokine System and Arthritis -- Chemokine Receptors in Atherosclerosis -- Chemokine Receptors in Allergic Lung Disease -- Chemokine Receptors and HIV/AIDS -- Chemokines and Their Receptors in Fibrosis -- Chemokines and Angiogenesis -- Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets -- Chemokine Receptors in Neuroinflammation -- Pharmaceutical Targeting of Chemokine Receptors.

To date, there are over twenty different chemokine receptors, binding nearly fifty unique ligands that have been identified. In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. Chemokines exhibit a tremendous functional diversity and participate in a wide variety of processes that include inflammation, innate and adaptive immunity, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology and viral pathogenesis. Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics.

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