Systems Biology : Applications and Perspectives / edited by P. Bringmann, E. C. Butcher, G. Parry, B. Weiss.

Springer eBooks

RNAi Applications in Target Validation -- Does the Serum Peptidome Reveal Hemostatic Dysregulation? -- Systems Biology: New Paradigms for Cell Biology and Drug Design -- The Theory of Biological Robustness and Its Implication in Cancer -- Network Genomics -- A Plea for More Theory in Molecular Biology -- Applying a Causal Framework to System Modeling -- Can Cell Systems Biology Rescue Drug Discovery?.

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Overwhelming data sets are generated ever faster, providing enormous detail. In order to be useful, however, all these data must be appropriately integrated, analyzed in the context of all other information available and eventually modelled, enabling predictions for therapeutic interventions. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

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