PET Chemistry : The Driving Force in Molecular Imaging / edited by P. A. Schubiger, L. Lehmann, M. Friebe.

Springer eBooks

Molecular Imaging with PET — Open Questions? -- Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions -- Fluorine-18 Labeling of Small Molecules: The Use of 18F-Labeled Aryl Fluorides Derived from No-Carrier-Added [18F]Fluoride as Labeling Precursors -- Fluorine-18 Labeling of Peptides and Proteins -- [18F]Fluoropyridines: From Conventional Radiotracers to the Labeling of Macromolecules Such as Proteins and Oligonucleotides -- Production of Non-standard PET Radionuclides and the Application of Radiopharmaceuticals Labeled with these Nuclides -- Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide -- 68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy -- Microwaving in F-18 Chemistry: Quirks and Tweaks -- Micro-reactors for PET Tracer Labeling -- Synthesis Modules and Automation in F-18 Labeling -- Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research -- Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development.

The incessant progress in the comprehension of molecular processes of disease formation and progression is accompanied by an increasing importance of biomedical molecular imaging methods. PET, a nuclear medical imaging modality, is ideally suited to produce such kinds of images by use of positron-emitting chemical entities. The purpose of this workshop was to discuss and overview applications and technologies in the area of PET chemistry. The book provides the reader with state-of-the-art information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76, Br-77 and I-124, and their impact on molecular imaging. New technical features such as microwaves, microreactors and modules for the synthesis of new PET tracers are discussed.

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