Cell and Tissue Reaction Engineering : With a Contribution by Martin Fussenegger and Wilfried Weber / by Regine Eibl, Dieter Eibl, Ralf Pörtner, Gerardo Catapano, Peter Czermak.

Springer eBooks

Mammalian Cells -- Mammalian Cell Culture Technology: An Emerging Field -- Characteristics of Mammalian Cells and Requirements for Cultivation -- Bioreactors for Mammalian Cells: General Overview -- Special Engineering Aspects -- Bioreactor Design and Scale-Up -- Special Applications -- Insect Cell-Based Recombinant Protein Production -- Bioreactors for Bioartificial Organs -- Plant Cell-Based Bioprocessing.

Today mammalian cell products, primarily monoclonals, cytokines, recombinant glycoproteins and increasingly vaccines dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells for regenerative medicine have been introduced on the market. This book elucidates the interactions between biological as well as biochemical and engineering principles in processes derived from cell cultures. The authors explain the basic characteristics of mammalian cells related to cultivation systems and the consequences on design and operation of bioreactor systems, so that the importance of cell culture technology as well as differences compared to microbial fermentation technology are understood. Further, special cell culture applications, such as insect cell-based recombinant protein production, bioartificial organs and plant cell-based bioprocessing, are presented. This book is of interest to students of biotechnology as well as scientists and industrial users.

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