000 05016nam a22003735i 4500
001 277253
003 MX-SnUAN
005 20160429153812.0
007 cr nn 008mamaa
008 150903s2009 xxu| o |||| 0|eng d
020 _a9780387096063
_9978-0-387-09606-3
024 7 _a10.1007/9780387096063
_2doi
035 _avtls000329698
039 9 _a201509030443
_bVLOAD
_c201404121649
_dVLOAD
_c201404091427
_dVLOAD
_c201401311315
_dstaff
_y201401291438
_zstaff
_wmsplit0.mrc
_x121
050 4 _aR-RZ
100 1 _aMaroto, Miguel.
_eeditor.
_9299809
245 1 0 _aSomitogenesis /
_cedited by Miguel Maroto, Neil V. Whittock.
264 1 _aNew York, NY :
_bSpringer New York,
_c2009.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v638
500 _aSpringer eBooks
505 0 _aFormation and Differentiation of Avian Somite Derivatives -- Avian Somitogenesis: Translating Time and Space into Pattern -- Genetic Analysis of Somite Formation in Laboratory Fish Models -- Old Wares and New: Five Decades of Investigation of Somitogenesis in Xenopus laevis -- Role of Delta-Like-3 in Mammalian Somitogenesis and Vertebral Column Formation -- Mesp-Family Genes Are Required for Segmental Patterning and Segmental Border Formation -- bHLH Proteins and Their Role in Somitogenesis -- Mouse Mutations Disrupting Somitogenesis and Vertebral Patterning -- Defective Somitogenesis and Abnormal Vertebral Segmentation in Man.
520 _aWe visualise developmental biology as the study of progressive changes that occur within cells, tissues and organisms themselves during their life span. A good example of a field of developmental biology in which this concept is encapsulated is that of somitogenesis. The somite was identified as the primordial unit underlying the segmented organisation of vertebrates more than two centuries ago. The spectacular discoveries and achievements in molecular biology in the last fifty years have created a gene-based revolution in both the sorts of questions as well as the approaches one can use in developmental biology today. Largely as a result of this, during the 20th and 21st centuries this simple structure, the somite, has been the focus of a deluge of papers addressing multiple aspects of somite formation and patterning both at the cellular and molecular level. One of the main reasons for such interest in the process of somitogenesis stems from the fact that it is such an exquisitely beautiful example of biology working under strict temporal and spatial control in a reiterative manner that is highly conserved across the vertebrate classes. Our intention is that this book will be of interest to different kinds of scientists, including basic researchers, pathologists, anatomists, teachers and students working in the fields of cell and developmental biology. The nine chapters cover a wide array of topics that endeavour to capture the spirit of this dynamic and ever-expanding discipline by integrating both contemporary research with the classical embryological literature that concentrated on descriptions of morphological changes in embryos and the interactions of cells and tissues during development. In so doing they encompass the main aspects of somitogenesis across four vertebrate classes (frog, fish, mouse and chick) and the hope is that this will enable readers to acquire an appreciation of this developmental process in all its facets. Each of the different animal models offers alternative strategic approaches (including experimental embryology, genetics and cell biology) to tackle the same process and as such each offers an invaluable and unique insight into different aspects of somitogenesis. The topics described in these chapters cover the generation of somitic tissue during gastrulation, the molecular mechanisms by which the unsegmented pre-somitic mesoderm becomes segmented into somites, the generation of polarity within somites and the means by which the somite is directed to differentiate into a number of different cell derivatives. There are also two chapters devoted to describing the latest developments on relating spontaneous mouse mutations and mutations leading to abnormal vertebral segmentation in man to the molecular mechanisms already identified as being crucial for somite formation in the lower vertebrates.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aWhittock, Neil V.
_eeditor.
_9299857
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387096056
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-09606-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c277253
_d277253