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020 _a9780387097893
_9978-0-387-09789-3
024 7 _a10.1007/9780387097893
_2doi
035 _avtls000329782
039 9 _a201509030401
_bVLOAD
_c201404121705
_dVLOAD
_c201404091442
_dVLOAD
_c201401311318
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050 4 _aR-RZ
100 1 _aSigalov, Alexander B.
_eeditor.
_9300417
245 1 0 _aMultichain Immune Recognition Receptor Signaling :
_bFrom Spatiotemporal Organization to Human Disease /
_cedited by Alexander B. Sigalov.
264 1 _aNew York, NY :
_bSpringer New York,
_c2008.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v640
500 _aSpringer eBooks
505 0 _aMIRRs: Structure and Physiological Function -- T-Cell Receptor -- B-Cell Receptor -- Fc Receptors -- Natural Killer Cell Receptors -- Platelet Glycoprotein VI -- MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize -- Clustering Models -- Segregation Models -- Kinetic Proofreading Model -- Serial Triggering Model -- Conformational Model -- Permissive Geometry Model -- Signaling Chain Homooligomerization (SCHOOL) Model -- Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses -- Visualization of Protein Interactions in Living Cells -- MIRR Signaling and Therapy of Immune Disorders -- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences -- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides -- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer -- Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease -- MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines -- SCHOOL Model and New Targeting Strategies -- Immune Receptor Signaling, Aging and Autoimmunity -- Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment.
520 _aThis book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transduction will be shortly reviewed in Section 3. This book will summarize our current knowledge in this field and illustrate how control of the MIRR-triggered signaling could become a potential target of medical intervention, thus bridging basic and clinical immunology.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387097886
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-09789-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c277551
_d277551