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020 _a9780387254463
_9978-0-387-25446-3
024 7 _a10.1007/b107412
_2doi
035 _avtls000330150
039 9 _a201509031111
_bVLOAD
_c201405070500
_dVLOAD
_c201401311331
_dstaff
_c201401311155
_dstaff
_y201401291448
_zstaff
_wmsplit0.mrc
_x570
050 4 _aRC321-580
100 1 _aLecea, Luis.
_eeditor.
_9302297
245 1 0 _aHypocretins :
_bIntegrators of Physiological Functions /
_cedited by Luis Lecea, J. Gregor Sutcliffe.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXXIII, 439 páginas,
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aDiscovery of the Hypocretins/Orexins and Their Receptors -- The Discovery of the Hypocretins -- Orexin and Orexin Receptors -- Animal Models in the Study of the Hypocretinergic System -- Rodent Models of Human Narcolepsy-cataplexy -- The Canine Model of Narcolepsy -- Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits -- Anatomy of the Hypocretin System -- The Anatomy of Hypocretin Neurons -- Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalamic Area -- Physiological Consequences of Hypocretin Activation -- Physiological Characteristics of Hypocretin/Orexin Neurons -- The Ne System as a Target for Hypocretin Neurons -- Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State -- The Aminergic Systems and the Hypocretins -- Effects Of Hypocretin/Orexin on the Thalamocortical Activating System -- Pharmacology of the Hypocretins and Drug Design -- In Vivo Pharmacology of Orexin (Hypocretin) Receptors -- Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors -- The Hypocretins in Narcolepsy and Arousal -- The Hypocretins and Narcolepsy -- An Approach to Determining the Functions of Hypocretin (Orexin) -- Hypocretin in Neuropsychiatric Disorders -- Hypocretin/Orexin and Sleep -- Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin -- The Hypocretins in Feeding and Energy Balance -- Regulation of Hypocretin by Metabolic Signals -- The Hypocretins in Addiction and Hyperarousal -- Hypocretin and Brain Reward Function -- Orexin/Hypocretin and Opioid Dependence -- Dopamine-Hypocretin/Orexin Interactions -- Hypocretin/Orexin in Stress and Arousal -- Role of Hypocretins on Peripheral Systems -- The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis -- Orexins (Hypocretins) in the Gut -- Hypocretins in Endocrine Regulation -- The Hypocretins in Cardiovascular Regulation.
520 _aThe hypocretins (orexins) are a newly identified (1998) peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides, located primarily in the hypothalmus, in the regulation of behavioral state. They are involved in circadian rhythms, metabolism, hormone secretion, body temperature, appetite, cardiovascular functions (e.g., blood pressure), and sleep abnormalities (e.g., narcolepsy and cataplexy).
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aSutcliffe, J. Gregor.
_eeditor.
_9302298
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387250007
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/b107412
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c278581
_d278581