000 03611nam a22003735i 4500
001 279278
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008 150903s2008 xxu| o |||| 0|eng d
020 _a9780387788876
_99780387788876
024 7 _a10.1007/9780387788876
_2doi
035 _avtls000332969
039 9 _a201509030222
_bVLOAD
_c201404122319
_dVLOAD
_c201404092056
_dVLOAD
_y201402041059
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC321-580
100 1 _aTsai, Li-Huei.
_eeditor.
_9303512
245 1 0 _aCyclin Dependent Kinase 5 (Cdk5) /
_cedited by Li-Huei Tsai, Nancy Y. Ip.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2008.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aCdk5/p35 Regulates Neuronal Migration -- CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration -- Cdk5 in Presynapses -- Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release -- Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling -- Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival -- CDK5 and Mitochondrial Cell Death Pathways -- Regulation and Function of Cdk5 in the Nucleus -- Cdk5 May Be an Atypical Kinase, but Not in the Way You Think -- Cdk5 and Neuregulin-1 Signaling -- Cyclin-Dependent Kinase 5 and Insulin Secretion -- Protein–Protein Interactions Involving the N-Terminus of p35 -- The Kinase Activity of Cdk5 and Its Regulation -- The Structural Bases of CDK5 Activity -- Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting -- Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory -- Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration -- Cdk5 as a Drug Target for Alzheimer’s Disease.
520 _aCyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aIp, Nancy Y.
_eeditor.
_9303513
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387788869
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-78887-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c279278
_d279278