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020 _a9780387775760
_99780387775760
024 7 _a10.1007/9780387775760
_2doi
035 _avtls000332835
039 9 _a201509030209
_bVLOAD
_c201404122253
_dVLOAD
_c201404092023
_dVLOAD
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040 _aMX-SnUAN
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_cMX-SnUAN
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050 4 _aRB155-155.8
100 1 _aWilkins, Jon F.
_eeditor.
_9303977
245 1 0 _aGenomic Imprinting /
_cedited by Jon F. Wilkins.
264 1 _aNew York, NY :
_bSpringer New York,
_c2008.
300 _axvii, 125 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v626
500 _aSpringer eBooks
505 0 _aDNA Methylation Reprogramming in the Germ Line -- Control of Imprinting at the Gnas Cluster -- The GNAS Locus and Pseudohypoparathyroidism -- Imprinted Genes, Postnatal Adaptations and Enduring Effects on Energy Homeostasis -- What Are Imprinted Genes Doing in the Brain? -- Genomic Imprinting and Human Psychology: Cognition, Behavior and Pathology -- Genomic Imprinting in Plants -- Imprinted Genes and Human Disease: An Evolutionary Perspective -- Evolutionary Theories of Imprinting— Enough Already!.
520 _aGenomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father. This difference in expression strategy correlates with differences in the epigenetic state of the two alleles. These epigenetic differences include DNA methylation at CpG dinucleotides, as well as modifications on the histones associated with the locus. In the simplest possible cases, the promoter region of the imprinted gene is methylated during oogenesis, but not spermatogenesis (or vice versa). This methylation (and its accompanying histone modifications) results in inactivation of the modified allele. Of course, most imprinted genes do not fall into this simplest case. The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field (which would necessarily span multiple books). Rather, the book covers on some of the more recent advances, with the goal of drawing attention to some of the emerging subtleties and complexities associated with imprinted genes.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387775753
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-77576-0
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c279575
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