000 03650nam a22003735i 4500
001 279699
003 MX-SnUAN
005 20160429153955.0
007 cr nn 008mamaa
008 150903s2007 xxu| o |||| 0|eng d
020 _a9780387768427
_99780387768427
024 7 _a10.1007/9780387768427
_2doi
035 _avtls000332747
039 9 _a201509030758
_bVLOAD
_c201404122237
_dVLOAD
_c201404092007
_dVLOAD
_y201402041037
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aPawelec, Graham.
_eautor
_9304171
245 1 0 _aImmunosenescence /
_cby Graham Pawelec.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aMedical Intelligence Unit
500 _aSpringer eBooks
505 0 _aImmune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study -- Scoring of Immunological Vigor: Trial Assessment of Immunological Status as a Whole for Elderly People and Cancer Patients -- Remodelling of the CD8 T-Cell Compartment in the Elderly: Expression of NK Associated Receptors on T-Cells Is Associated with the Expansion of the Effector Memory Subset -- Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infection -- A Matter of Life and Death of T-Lymphocytes in Immunosenescence -- T-Cell Signalling, a Complex Process for T-Cell Activation Compromised with Aging: When Membrane Rafts Can Simplify Everything -- Immunosenescence, Thymic Involution and Autoimmunity -- Autoimmune Diseases, Aging and the CD4+ Lymphocyte: Why Does Insulin-Dependent Diabetes Mellitus Start in Youth, but Rheumatoid Arthritis Mostly at Older Age? -- Role of Chemokines and Chemokine Receptors in Diseases of Ageing -- The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly -- Zinc and the Altered Immune System in the Elderly -- Zinc-Binding Proteins and Immunosenescence: Implications as Biological and Genetic Markers -- Immunogenetics of Aging -- The Genetics of Innate Immunity and Inflammation in Ageing, Age-Related Diseases and Longevity -- SELDI Proteomics Approach to Identify Proteins Associated with T-Cell Clone Senescence.
520 _aHuman immunosenescence contributes to morbidity and mortality in later life. The age-associated increasing incidence of cancer and cardiovascular disease plateaus at around 80 years of age in industrialised countries, but death due to infectious disease continues to increase up to 100 years of age and beyond. Understanding the reasons for age-associated alterations to protective immunity in the elderly would facilitate the development of interventions to reconstitute appropriate immune function, increase responsiveness to vaccination and extend healthspan. The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387768403
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-76842-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c279699
_d279699