000			04858nam a22003735i 4500
001			279788
003			MX-SnUAN
005			20160429153958.0
007			cr nn 008mamaa
008			150903s2012 xxu| o |||| 0|eng d
020			_a9780387698052 _99780387698052
024	7		_a10.1007/9780387698052 _2doi
035			_avtls000332035
039		9	_a201509030213 _bVLOAD _c201404122013 _dVLOAD _c201404091739 _dVLOAD _y201402041019 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC261-271
100	1		_aGreen, Jeffrey E. _eeditor. _9304306
245	1	0	_aGenetically Engineered Mice for Cancer Research : _bdesign, analysis, pathways, validation and pre-clinical testing / _cedited by Jeffrey E. Green, Thomas Ried.
264		1	_aNew York, NY : _bSpringer New York, _c2012.
300			_axx, 632 páginas 75 ilustraciones, 47 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
500			_aSpringer eBooks
505	0		_aForeword -- Preface -- Overview of Designing Genetically-Engineered Mouse Models -- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer -- Using Recombineering Technology To Create Genetically Engineered Mouse Models -- Insertional Mutagenesis for Generating Mouse Models of Cancer -- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer -- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat -- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology -- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry -- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying Mammary Epithelial Stem and Progenitor Cells -- Differentiation Programs in Development and Cancer -- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse -- Mouse Models for Colorectal Cancer -- Src family tyrosine kinases: Implications for mammary tumor progression -- Maspin and Suppression of Tumor Metastasis -- Epigenetic Mouse Models -- Modeling Transforming Growth Factor-ß Signaling in Cancer -- Modeling Stromal-Epithelial Interactions.-  Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.-  Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models -- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models -- Animal Models for Breast Cancer Prevention Resarch -- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies -- Mouse Models in Preclinical Drug Development- Applications to CNS Models -- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine -- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development -- Index.  .
520			_aTechnological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aRied, Thomas. _eeditor. _9304307
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9780387698038
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-69805-2 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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