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008 | 150903s2010 xxu| o |||| 0|eng d | ||
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_a9780387686363 _99780387686363 |
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024 | 7 |
_a10.1007/9780387686363 _2doi |
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_a201509030208 _bVLOAD _c201404121948 _dVLOAD _c201404091715 _dVLOAD _y201402041015 _zstaff |
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_aMX-SnUAN _bspa _cMX-SnUAN _erda |
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050 | 4 | _aQA276-280 | |
100 | 1 |
_aHalloran, M. Elizabeth. _eautor _9304557 |
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245 | 1 | 0 |
_aDesign and Analysis of Vaccine Studies / _cby M. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner. |
264 | 1 |
_aNew York, NY : _bSpringer New York, _c2010. |
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300 | _brecurso en línea. | ||
336 |
_atexto _btxt _2rdacontent |
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_acomputadora _bc _2rdamedia |
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_arecurso en línea _bcr _2rdacarrier |
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_aarchivo de texto _bPDF _2rda |
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490 | 0 |
_aStatistics for Biology and Health, _x1431-8776 |
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500 | _aSpringer eBooks | ||
505 | 0 | _aand Examples -- Overview of Vaccine Effects and Study Designs -- Immunology and Early Phase Trials -- Binomial and Stochastic Transmission Models -- and Deterministic Models -- Evaluating Protective Effects of Vaccination -- Modes of Action and Time-Varying VE -- Further Evaluation of Protective Effects -- Vaccine Effects on Post-Infection Outcomes -- Household-Based Studies -- Analysis of Households in Communities -- Analysis of Independent Households -- Assessing Indirect, Total, and Overall Effects -- Randomization and Baseline Transmission -- Surrogates of Protection. | |
520 | _aWidespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at the individual and at the population level. The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness. The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. Topics include household studies, evaluating correlates of immune protection, and applications of casual inference. Material on concepts of infectious disease epidemiology, transmission models, casual inference, and vaccines provides background for the reader. This is the first book to present vaccine evaluation in this comprehensive conceptual framework. This book is intended for colleagues and students in statistics, biostatistics, epidemiology, and infectious diseases. Most essential concepts are described in simple language accessible to epidemiologists, followed by technical material accessible to statisticians. M. Elizabeth Halloran and Ira Longini are professors of biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Claudio Struchiner is professor of epidemiology and biostatistics at the Brazilian School of Public Health of the Oswaldo Cruz Foundation in Rio de Janeiro. The authors are prominent researchers in the area. Halloran and Struchiner developed the study designs for dependent happenings to delineate indirect, total, and overall effects. Halloran has made contributions at the interface of epidemiological methods, causal inference, and transmission dynamics. Longini works in the area of stochastic processes applied to epidemiological infectious disease problems, specializing in the mathematical and statistical theory of epidemics. Struchiner has contributed to understanding the role of transmission in interpreting vaccine effects. | ||
590 | _aPara consulta fuera de la UANL se requiere clave de acceso remoto. | ||
700 | 1 |
_aLongini, Jr., Ira M. _eautor _9304558 |
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700 | 1 |
_aStruchiner, Claudio J. _eautor _9304559 |
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710 | 2 |
_aSpringerLink (Servicio en línea) _9299170 |
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776 | 0 | 8 |
_iEdición impresa: _z9780387403137 |
856 | 4 | 0 |
_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-68636-3 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL) |
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