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008 150903s2008 xxu| o |||| 0|eng d
020 _a9780387691183
_99780387691183
024 7 _a10.1007/9780387691183
_2doi
035 _avtls000331990
039 9 _a201509030212
_bVLOAD
_c201404122004
_dVLOAD
_c201404091731
_dVLOAD
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_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aGabrilovich, Dmitry I.
_eeditor.
_9304578
245 1 0 _aTumor-Induced Immune Suppression :
_bMechanisms and Therapeutic Reversal /
_cedited by Dmitry I. Gabrilovich, Arthur A. Hurwitz.
264 1 _aNew York, NY :
_bSpringer New York,
_c2008.
300 _aIx, 301 páginas 50 ilustraciones
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aImmune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions -- Mechanisms of Tumor-Associated T-Cell Tolerance -- Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer -- Regulatory T Cells in Cancer -- Cancer-Induced Signaling Defects in Antitumor T Cells -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Myeloid-Derived Suppressor Cells in Cancer -- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Arginine Availability Regulates T-Cell Function in Cancer -- Protein–Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3 -- Role of Reactive Oxygen Species in T-Cell Defects in Cancer -- Tumor Stroma and the Antitumor Immune Response.
520 _aTumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on: Different surface molecules that mediate T-cell suppression in cancer; The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness; The contribution of regulatory T cells in the inability of immune systems to mount antitumor response; The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression. This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction. This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aHurwitz, Arthur A.
_eeditor.
_9304579
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387691176
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-69118-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c279965
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