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008			150903s2007 xxu| o |||| 0|eng d
020			_a9780387399782 _99780387399782
024	7		_a10.1007/9780387399782 _2doi
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040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC261-271
100	1		_aMocellin, Simone. _eeditor. _9304621
245	1	0	_aMicroarray Technology and Cancer Gene Profiling / _cedited by Simone Mocellin.
264		1	_aNew York, NY : _bSpringer New York, _c2007.
300			_axviii, 159 páginas, _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v593
500			_aSpringer eBooks
505	0		_aMicroarray Technology -- Manufacturing of Microarrays -- Technological Platforms for Microarray Gene Expression Profiling -- Principles of Gene Microarray Data Analysis -- Gaining Weights ... and Feeling Good about It! -- Complementary Techniques -- Complementary Techniques -- Complementary Techniques -- Applications in the Oncology Field -- Microarrays for Cancer Diagnosis and Classification -- Gene Profiling for the Prediction of Tumor Response to Treatment -- Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs -- SNP and Mutation Analysis -- Cancer Development and Progression -- Gene Expression Profiling in Malignant Lymphomas -- Tumor Immunology.
520			_aCancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9780387399775
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-39978-2 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c279995 _d279995