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020 _a9780387465302
_99780387465302
024 7 _a10.1007/0387465308
_2doi
035 _avtls000331507
039 9 _a201509030721
_bVLOAD
_c201404120629
_dVLOAD
_c201404090409
_dVLOAD
_c201401311417
_dstaff
_y201401301211
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQR180-189.5
100 1 _aGupta, Sudhir.
_eeditor.
_9302361
245 1 0 _aMechanisms of Lymphocyte Activation and Immune Regulation XI :
_bB Cell Biology /
_cedited by Sudhir Gupta, Frederick Alt, Max Cooper, Fritz Melchers, Klaus Rajewsky.
264 1 _aBoston, MA :
_bSpringer US,
_c2007.
300 _ax, 196 páginas,
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v596
500 _aSpringer eBooks
505 0 _aRegulation and Function of the E2A Proteins in B Cell Development -- Multiple Roles for Blimp-1 in B and T Lymphocytes -- Memory B Cell Evolution: B Cell Biology -- BCR-linked Factors in Developmental Fate Decisions -- Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors -- Rules for the Rearrangement Events at the L Chain Gene Loci of the Mouse -- Regulation of AID Function In Vivo -- Targeting of AID to Immunoglobulin Genes -- Targeting AID to the Ig Genes -- DNA Replication to Aid Somatic Hypermutation -- Regulation of Activation Induced Deaminase via Phosphorylation -- Modulation of MHC Class II Signal Transduction by CD19 -- Role of NFUP?B Signaling in Normal and Malignant B Cell Development -- Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function -- Tolerance Mechanisms in the Late Phase of the Antibody Response -- Role of RS/?DE in B Cell Receptor Editing -- The Regulation of Receptor Editing -- B Cell Hyporesponsiveness and Autoimmunity: A New Paradigm.
520 _aIn recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aAlt, Frederick.
_eeditor.
_9304802
700 1 _aCooper, Max.
_eeditor.
_9304803
700 1 _aMelchers, Fritz.
_eeditor.
_9304804
700 1 _aRajewsky, Klaus.
_eeditor.
_9304805
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387465272
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/0-387-46530-8
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c280099
_d280099