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020 _a9780387706306
_99780387706306
024 7 _a10.1007/9780387706306
_2doi
035 _avtls000332054
039 9 _a201509030733
_bVLOAD
_c201404122016
_dVLOAD
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_dVLOAD
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040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQH573-671
100 1 _aWu, Hao.
_eeditor.
_9304820
245 1 0 _aTNF Receptor Associated Factors (TRAFs) /
_cedited by Hao Wu.
264 1 _aNew York, NY :
_bSpringer New York,
_c2007.
300 _axIx, 206 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v597
500 _aSpringer eBooks
505 0 _aPhylogeny of the TRAF/MATH Domain -- TRAF1 and Its Biological Functions -- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5 -- TRAF3 and Its Biological Function -- TRAF4, the Unique Family Member -- Characteristics and Biological Functions of TRAF6 -- Ubiquitination and TRAF signaling -- Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway -- Protein-Protein Interactions in TRAF3 -- Molecular Basis for the Unique Specificity of TRAF6 -- TRAF Proteins in CD40 Signaling -- TRAFs in RANK Signaling -- The LT?R Signaling Pathway -- LMP1 TRAFficking Activates Growth and Survival pathways -- Targeting TRAFs for Therapeutic Intervention.
520 _aIt has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387706290
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-70630-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c280109
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