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020 _a9780387690766
_99780387690766
024 7 _a10.1007/9780387690766
_2doi
035 _avtls000331984
039 9 _a201509030204
_bVLOAD
_c201404122003
_dVLOAD
_c201404091730
_dVLOAD
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_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
100 1 _aDe Wulf, Peter.
_eeditor.
_9304968
245 1 4 _aThe Kinetochore: :
_bFrom Molecular Discoveries to Cancer Therapy /
_cedited by Peter De Wulf, William C. Earnshaw.
264 1 _aNew York, NY :
_bSpringer New York,
_c2009.
300 _axiii, 516 páginas With 4-page color insert.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aCentromeres and Kinetochores: An Historical Perspective -- The Basics of Chromosome Segregation -- The Centromere -- Neocentromeres -- Human Artificial Centromeres: Assembly of Functional Centromeres on Human Artificial Chromosomes -- Kinetochore Composition, Formation, and Organization -- Evolution of Centromeres and Kinetochores: A Two-Part Fugue -- Mitotic Spindle Assembly Mechanisms -- Kinetochore-Microtubule Interactions -- Post-Translational Modifications that Regulate Kinetochore Activity -- The Role of the Kinetochore in Spindle Checkpoint Signaling -- Kinetochore Regulation of Anaphase and Cytokinesis -- Roles of Centromeres and Kinetochores in Meiosis -- The Kinetochore-Cancer Connection -- The Kinetochore as Target for Cancer Drug Development.
520 _aKinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aEarnshaw, William C.
_eeditor.
_9304969
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387690735
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-69076-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c280194
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