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020 _a9780387707655
_99780387707655
024 7 _a10.1007/9780387707655
_2doi
035 _avtls000332063
039 9 _a201509030734
_bVLOAD
_c201404122018
_dVLOAD
_c201404091744
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_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQP351-495
100 1 _aGaultier, Claude.
_eautor
_9304977
245 1 0 _aGenetic Basis for Respiratory Control Disorders /
_cby Claude Gaultier.
264 1 _aBoston, MA :
_bSpringer US,
_c2008.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aRespiratory control disorders: from genes to patients and back -- Hereditary aspects of respiratory control in health and disease in humans -- Phox2b and the homeostatic brain -- Congenital central hypoventilation syndrome: from patients to gene discovery -- Structural and functional brain abnormalities in Congenital Central Hypoventilation Syndrome -- In vitro studies of PHOX2B gene mutations in congenital central hypoventilation syndrome -- Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation -- The genetic basis for obstructive sleep apnea: what role for variation in respiratory control? -- Apnea and irregular breathing in animal models: a physiogenomic approach -- Genetic determinants of respiratory phenotypes in mice -- Genes and development of respiratory rhythm generation -- Transcription factor control of central respiratory neuron development -- Lessons from mutant newborn mice with respiratory control deficits -- Tentative mouse model for the congenital central hypoventilation syndrome: heterozygous phox2b mutant newborn mice -- Respiratory control abnormalities in necdinnull mice: implications for the pathogenesis of Prader-Willi syndrome -- Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome -- Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders?.
520 _aGenetic Basis for Respiratory Control Disorders provides an overview of the recent knowledge of the genetic factors underlying respiratory control disorders, an emerging field in respiratory biology. Identifying genes involved in respiratory control is crucial for understanding human diseases characterized by abnormal respiratory control, such as Prader-Willi syndrome, Rett syndrome, congenital central hypoventilation syndrome (CCHS), obstructive sleep apnea syndrome (OSAS), central sleep apnea syndrome, apneas of prematurity and sudden infant death syndrome (SIDS). Furthermore, genetic factors play a key role in respiratory control adaptation in health and disease, most notably in the respiratory response to intermittent hypoxia. The objective of the book is to supply state-of-the-art contributions about all aspects of respiratory control genetics, from the molecular to the system level. The book aims to review the full spectrum of available knowledge, which starts with early physiological studies in health and disease in humans and studies in rodents that suggested a hereditary component to respiratory control. The spectrum extends to recent work elucidating crucial molecular aspects of respiratory control development, from early embryonic specifications in the neural tube to the function of respiratory rhythm generators. Developmental programs and gene expression profiles of different neuron types in the respiratory-control neuronal network have been characterized, together with their control by specific sets of transcription factors. In mice, targeted inactivation of several transcription factors disrupts the development of specific respiratory-neuron groups and causes abnormal respiratory phenotypes. These effects are described in detail in the book, with . a special attention to was given to the role of the transcription factor Phox2b. The developmental and respiratory phenotypes in newborn mice with Phox2b gene deletion and in vitro investigations of human mutated PHOX2B proteins have shed light on the pathogenesis of CCHS. Respiratory control abnormalities in necdin-null mice and in mice lacking Mecp2 gene have provided new insights into the developmental origins of the respiratory disorders seen in Prader-Willi and Rett syndromes, respectively. Current genetic data in complex and multi-factorial respiratory disorders, including SIDS and OSAS, are described. Genetic Basis for Respiratory Control Disorders emphasizes the potent synergy between human studies and mouse models of genetic disorders underlying respiratory control anomalies. The overview of current research presented in this book opens up the field to the development of new therapeutic strategies, especially in newborns and infants, who are the primary target of respiratory control disorders. This book is addressed to pediatricians, neonatologists, pulmonologists, respiratory physiologists as well as geneticists.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387707648
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-70765-5
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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