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008 150903s2006 xxu| o |||| 0|eng d
020 _a9780387472577
_99780387472577
024 7 _a10.1007/9780387472577
_2doi
035 _avtls000331523
039 9 _a201509030755
_bVLOAD
_c201404121855
_dVLOAD
_c201404091623
_dVLOAD
_c201401311418
_dstaff
_y201401301211
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRB155-155.8
100 1 _aSilverman, Scott K.
_eautor
_9305339
245 1 0 _aNucleic Acid Switches and Sensors /
_cby Scott K. Silverman.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aIx, 125 páginas,
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aArtificial Nucleic Acid Switches and Sensors -- Allosteric Ribozymes as Molecular Switches and Sensors -- Ribozymes and Deoxyribozymes Switched by Oligonucleotides -- Ribozymes Switched by Proteins -- Fluorescence-Signaling Nucleic Acid-Based Sensors -- Natural Nucleic Acid Switches and Sensors -- Protein-Induced RNA Switches in Nature -- Riboswitches as Genetic Control Elements -- Switchable RNA Motifs as Drug Targets.
520 _aIn this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9780387374918
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-0-387-47257-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999 _c280425
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