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003 MX-SnUAN
005 20160429154107.0
007 cr nn 008mamaa
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020 _a9781402031861
_99781402031861
024 7 _a10.1007/9781402031861
_2doi
035 _avtls000334260
039 9 _a201509030804
_bVLOAD
_c201404300254
_dVLOAD
_y201402041143
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aSchulz, Wolfgang Arthur.
_eautor
_9307171
245 1 0 _aMolecular Biology of Human Cancers :
_bAn Advanced Student's Textbook /
_cby Wolfgang Arthur Schulz.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2005.
300 _axIx, 508 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aMolecules, Mechanisms, And Cells -- An Introduction to Human Cancers -- An Introduction to Human Cancers -- DNA Damage and DNA Repair -- Oncogenes -- Tumor Suppressor Genes -- Cancer Pathways -- Apoptosis and Replicative Senescence in Cancer -- Cancer Epigenetics -- Invasion and metastasis -- Human Cancers -- Leukemias and Lymphomas -- Wilms Tumor (nephroblastoma) -- Cancers of the skin -- Colon Cancer -- Bladder Cancer -- Renal Cell Carcinoma -- Liver Cancer -- Stomach Cancer -- Breast Cancer -- Prostate Cancer -- Prevention, Diagnosis, And Therapy -- Cancer Prevention -- Cancer Diagnosis -- Cancer Therapy.
520 _aOver the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402031854
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-3186-1
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c281471
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