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020			_a9781402041426 _99781402041426
024	7		_a10.1007/140204142-X _2doi
035			_avtls000334640
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040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aR-RZ
100	1		_aIonescu, Corina. _eeditor. _9307405
245	1	0	_aDrug Metabolism : _bCurrent Concepts / _cedited by Corina Ionescu, Mino R. Caira.
264		1	_aDordrecht : _bSpringer Netherlands, _c2005.
300			_ax, 420 páginas _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
500			_aSpringer eBooks
505	0		_aDrug Metabolism In Context: Introduction -- Absorption -- Drug Distribution -- Dynamics Of Drug Action -- Drug Clearance -- Dynamics Of Drug Clearance -- Pathways Of Biotransformation – Phase I Reactions: Introduction -- Phase I And Phase Ii Metabolism: General Considerations -- Oxidations Involving The Microsomal Mixed-Function Oxidase System -- Oxidations Involving Other Enzymatic Systems -- Metabolic Reactions Involving Reduction -- Hydrolysis -- Miscellanous Phase I Reactions -- The Fate Of Phase I Reaction Products -- . Pathways Of Biotransformation – Phase I Reactions: Introduction -- Glucuronidation -- Acetylation -- Glutathione Conjugation -- Other Conjugative Reactions -- Concluding Remarks -- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction -- Interaction Between A Drug Substrate And An Enzyme -- Enzyme Systems With Specific Roles -- Final Remarks -- Induction And Inhibition Of Drug-Metabolising Enzymes -- Introduction -- Induction -- Inhibition -- Consequences Of The Above Phenomena -- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition -- Factors That Influence Drug Biotransformation -- Introduction -- Intrinsic Factors -- Environmental Factors -- Further Observations -- Impact Of Gene Variability On Drug Metabolism -- Introduction -- Basic Principles Of Pharmacogenetics -- Pharmaco-Informatics -- Implications For Third Millennium Medicine -- Drug Interactions And Adverse Reactions: Introduction -- Drug-Drug Interactions -- Interactions Between Drugs And Other Entities -- Adverse Reactions -- Summary -- Strategies For Drug Design -- Introduction -- Pharmacokinetics And Metabolism In Drug Research -- The Role Of Formulation -- Concluding Remarks -- Index.
520			_aDrug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aCaira, Mino R. _eeditor. _9307406
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781402041419
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/1-4020-4142-X _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c281595 _d281595