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020 _a9781402036422
_99781402036422
024 7 _a10.1007/1402036426
_2doi
035 _avtls000334429
039 9 _a201509030246
_bVLOAD
_c201404120746
_dVLOAD
_c201404090526
_dVLOAD
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_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aEsteller, Manel.
_eeditor.
_9307605
245 1 0 _aDNA Methylation, Epigenetics and Metastasis /
_cedited by Manel Esteller.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2005.
300 _axI, 310 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aCancer Metastasis — Biology and Treatment,
_x1568-2102 ;
_v7
500 _aSpringer eBooks
505 0 _aHow CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes -- A Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible for Metastasis -- CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis -- CpG Island Hypermethylation Changes during Prostate Cancer Progression and Metastasis -- CpG Island Hypermethylation in Breast Cancer Progression and Metastasis -- Epigenetic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis -- Epigenetic Regulation of the E-Cadherin Cell-Cell Adhesion Gene -- Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer -- Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion -- The Molecular Mechanisms for Breast Cancer Metastasis Suppressor 1 Action in Cancer Metastasis -- Mechanisms of DNA Demethylating Drugs Against Cancer Progression -- Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents.
520 _aThis book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402036415
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/1-4020-3642-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c281688
_d281688