| 000 | 03521nam a22004335i 4500 | ||
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| 001 | 281694 | ||
| 003 | MX-SnUAN | ||
| 005 | 20160429154116.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 150903s2005 ne | o |||| 0|eng d | ||
| 020 |
_a9781402037641 _99781402037641 |
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| 024 | 7 |
_a10.1007/1402037643 _2doi |
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| 035 | _avtls000334488 | ||
| 039 | 9 |
_a201509030208 _bVLOAD _c201404120757 _dVLOAD _c201404090537 _dVLOAD _y201402041149 _zstaff |
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_aMX-SnUAN _bspa _cMX-SnUAN _erda |
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| 050 | 4 | _aRC261-271 | |
| 100 | 1 |
_aBack, Nathan. _eeditor. _9303793 |
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| 245 | 1 | 0 |
_aGenome Instability in Cancer Development / _cedited by Nathan Back, Irun R. Cohen, David Kritchevsky, Abel Lajtha, Rodolfo Paoletti, Erich A. Nigg. |
| 264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2005. |
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| 300 |
_axvI, 512 páginas _brecurso en línea. |
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| 336 |
_atexto _btxt _2rdacontent |
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| 337 |
_acomputadora _bc _2rdamedia |
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| 338 |
_arecurso en línea _bcr _2rdacarrier |
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| 347 |
_aarchivo de texto _bPDF _2rda |
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| 490 | 0 |
_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v570 |
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| 500 | _aSpringer eBooks | ||
| 505 | 0 | _aThe Multiplicity of Mutations in Human Cancers -- Monitoring Chromosome Rearrangements -- Nucleotide Excision Repair and its Connection with Cancer and Ageing -- DNA Mismatch Repair and Colon Cancer -- Base Excision Repair -- Genomic Instability in Cancer Development -- Translesion Synthesis And Errorprone Polymerases -- The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake? -- DNA Replication and Genomic Instability -- The Dream of Every Chromosome: Equal Segregation for a Healthy Life of the Host -- Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis -- Gene Amplification Mechanisms -- DNA Methylation and Cancer-associated Genetic Instability -- Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer -- Mammalian DNA Damage Response Pathway -- ATM and Cellular Response to DNA Damage -- Mitotic Checkpoint, Aneuploidy and Cancer. | |
| 520 | _aThis book reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. Reflecting recent discoveries and ongoing research, it discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Moreover, it summarises our current understanding of the various defects that may allow cancer cells to rapidly accumulate critical mutations and evolve, through processes reminiscent of Darwinian selection, an increasingly aggressive behaviour. Hopefully, this book will stimulate thought, discussion and experimentation, and serve as a rich source of information for a wide audience, including advanced students, researchers and clinical oncologists. | ||
| 590 | _aPara consulta fuera de la UANL se requiere clave de acceso remoto. | ||
| 700 | 1 |
_aCohen, Irun R. _eeditor. _9303794 |
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| 700 | 1 |
_aKritchevsky, David. _eeditor. _9307618 |
|
| 700 | 1 |
_aLajtha, Abel. _eeditor. _953872 |
|
| 700 | 1 |
_aPaoletti, Rodolfo. _eeditor. _960996 |
|
| 700 | 1 |
_aNigg, Erich A. _eeditor. _9307619 |
|
| 710 | 2 |
_aSpringerLink (Servicio en línea) _9299170 |
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| 776 | 0 | 8 |
_iEdición impresa: _z9781402037634 |
| 856 | 4 | 0 |
_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/1-4020-3764-3 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL) |
| 942 | _c14 | ||
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_c281694 _d281694 |
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