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001 281995
003 MX-SnUAN
005 20160429154129.0
007 cr nn 008mamaa
008 150903s2006 ne | o |||| 0|eng d
020 _a9781402047091
_99781402047091
024 7 _a10.1007/1402047096
_2doi
035 _avtls000334881
039 9 _a201509030249
_bVLOAD
_c201404120858
_dVLOAD
_c201404090637
_dVLOAD
_y201402041245
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aQH506
100 1 _aDijke, Peter ten.
_eeditor.
_9308240
245 1 0 _aSmad Signal Transduction :
_bSmads in Proliferation, Differentiation and Disease /
_cedited by Peter ten Dijke, Carl-Henrik Heldin.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2006.
300 _axiii.473 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aProteins and Cell Regulation ;
_v5
500 _aSpringer eBooks
505 0 _aMolecular Evolution of Smad Proteins -- C. Elegans TGF-? Signaling Pathways -- Smads In Drosophila – Interpretation Of Graded Signals In Vivo -- Delineating the TGF-?/Smad-Induced Cytostatic Response -- Smads In Mesenchymal Differentiation -- Smad Proteins in Apoptotic and Survival Signaling -- TGF-?/SMAD Signaling in Epithelial to Mesenchymal Transition -- Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer -- Trafficking of Serine/Threonine Kinase Receptors and Smad Activation -- Nucleocytoplasmic Shuttling of Smad Proteins -- Structural Insights into Smad Function and Specificity -- Regulation of Smad Function by Phosphorylation -- Regulation of Smad Functions Through Ubiquitination and Sumoylation Pathways -- Smad Transcriptional Co-Activators and Co-Repressors -- Integration of Signaling Pathways Via Smad Proteins -- Interplays Between The Smad and Map Kinase Signaling Pathways -- Gene Expression Signatures of TGF-?/Smad-Induced Responses -- Systems Biology Approaches to TGF-?/Smad Signaling -- Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases -- Alterations in Smad Signaling in Carcinogenesis -- TGF-? Receptor Kinase Inhibitors for the Treatment of Cancer -- TGF-? Receptor Kinase Inhibitors for Treatment of Fibrosis.
520 _aFor the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aHeldin, Carl-Henrik.
_eeditor.
_9308241
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402045424
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/1-4020-4709-6
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c281995
_d281995