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020 _a9781402060168
_99781402060168
024 7 _a10.1007/9781402060168
_2doi
035 _avtls000335440
039 9 _a201509030238
_bVLOAD
_c201404300301
_dVLOAD
_y201402041300
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC261-271
100 1 _aWeber, Georg F.
_eautor
_9308638
245 1 0 _aMolecular Mechanisms of Cancer /
_cby Georg F. Weber.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2007.
300 _axiv, 650 páginas
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aGeneral Mechanisms of Transformation -- Theories of Carcinogenesis -- Physiologic Correlates of Malignancy -- Alterations Intrinsic to the Tumor Cells -- Cell Division and Survival -- Cellular Senescence -- Invasiveness -- Mechanisms of Regulation of Cancer-related Genes -- DNA Repair -- Epigenetic Regulation of Cancer-Associated Gene Products -- Interaction of the Groups of Cancer-Related Gene Products -- Interactions Between Host and Tumor -- Structural Growth Control -- The Organ Preference of Metastasis Formation -- Angiogenesis -- Interactions with the Immune System -- Endocrine Dysregulation -- Dormancy and Minimal Residual Disease -- Molecular Mechanisms of Individual Malignancies -- Epithelial Tumors -- Hematologic Malignancies -- Mesenchymal Tumors -- Neurologic Tumors -- Tumors of Serous Cavities -- Embryonic Tumors.
520 _aThe knowledge of molecular defects that lead to cancer is increasing rapidly. This has created a need for a textbook that conveys a comprehensive review of this topic. "Molecular Mechanisms of Cancer", describes molecular processes whose deregulation is important in the formation of tumours. The material is developed from basic cell signalling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumour cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumour-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers. This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets. The growing insight generated by research into molecular carcinogenesis and the absence of comparably comprehensive and systematic textbooks makes this publication important and timely.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402060151
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-6016-8
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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