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008			150903s2008 ne | o |||| 0|eng d
020			_a9781402055256 _99781402055256
024	7		_a10.1007/9781402055256 _2doi
035			_avtls000335220
039		9	_a201509030236 _bVLOAD _c201404300258 _dVLOAD _y201402041254 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aQH505
100	1		_aLeuchtag, H. Richard. _eeditor. _9309591
245	1	0	_aVoltage-Sensitive Ion Channels : _bBiophysics of Molecular Excitability / _cedited by H. Richard Leuchtag.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
500			_aSpringer eBooks
505	0		_aExploring Excitability -- Information In The Living Body -- Animal Electricity -- Electrophysiology Of The Axon -- Aspects Of Condensed Matter -- Ions In The Electric Field -- Ions Drift And Diffuse -- Multi-Ion And Transient Electrodiffusion -- Models Of Membrane Excitability -- Admittance To The Semicircle -- What's That Noise? -- Ion Channels, Proteins And Transitions -- Diversity And Structures Of Ion Channels -- Microscopic Models Of Channel Function -- Order From Disorder -- Polar Phases -- Delicate Phases And Their Transitions -- Propagation And Percolation In A Channel -- Screws And Helices -- Voltage-Induced Gating Of Ion Channels -- Branching Out.
520			_aVoltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Because of their physiological functions, biochemical structures and electrical switching properties, they are at an intersection of biology, chemistry and physics. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book critically examines physically oriented approaches not covered in other ion-channel books. It looks at optical and thermal as well as electrical data, and at studies in the frequency domain as well as in the time domain. Rather than presenting the reader with only an option of mechanistic models at an inappropriate pseudo-macroscopic scale, it emphasizes concepts established in organic chemistry and condensed state physics. The book’s approach to the understanding of these unique structures breaks with the unproven view of ion channels as structurally gated pores. Rather, it proposes gateless gating, in which the onset and cessation of avalanches of ions crossing the membrane is explained as a cooperative phenomenon in a system poised far from equilibrium. These events, called channel opening and closing, are initiated by an electrical depolarization, a mechanical stimulus or even a thermal fluctuation.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781402055249
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-5525-6 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c282672 _d282672