000 04321nam a22004095i 4500
001 282848
003 MX-SnUAN
005 20160429154209.0
007 cr nn 008mamaa
008 150903s2008 ne | o |||| 0|eng d
020 _a9781402065613
_99781402065613
024 7 _a10.1007/9781402065613
_2doi
035 _avtls000335676
039 9 _a201509030240
_bVLOAD
_c201404300305
_dVLOAD
_y201402041306
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRC1-1245
100 1 _aMackness, Bharti.
_eeditor.
_9309906
245 1 4 _aThe Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism /
_cedited by Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2008.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aProteins And Cell Regulation ;
_v6
500 _aSpringer eBooks
505 0 _aThe Bert La Du Memorial Lecture -- Paraoxonases: An Historical Perspective -- PONs and Atherosclerosis -- Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form -- Paraoxonase-1 and Cardiovascular Disease -- Oxidative Stress & Antioxidants and PON1 in Health and Disease -- D-4F Increases Paraoxonase 1 Activity in HDL -- Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids -- The Role of PON2 and PON3 in Atherosclerosis and Related Traits -- Paraoxonase 1 and Postprandial Lipemia -- PON1 Genotypes and Coronary Heart Disease -- PON1 Structure -- Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents -- Stabilisation of Active Form of Natural Human PON1 Requires HPBP -- PONs in Disease other than Atherosclerosis -- Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection -- Age-Related Alterations in PON1 -- PON and Toxicology -- Paraoxonase (PON1) and Organophosphate Toxicity -- Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides -- PON-Genetics and Regulation -- Transcriptional Regulation of the Paraoxonase Genes -- Effect of Lipid Lowering Medications on PON1 -- The Functional Consequences of Polymorphisms in the Human PON1 Gene -- Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans -- PONs Biochemistry -- PONs’ Natural Substrates – The Key for their Physiological Roles -- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa.
520 _aResearch into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aMackness, Mike.
_eeditor.
_9309907
700 1 _aAviram, Michael.
_eeditor.
_9309908
700 1 _aParagh, György.
_eeditor.
_9309909
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402065606
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-6561-3
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942 _c14
999 _c282848
_d282848