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020 _a9781402089077
_99781402089077
024 7 _a10.1007/9781402089077
_2doi
035 _avtls000336202
039 9 _a201509030819
_bVLOAD
_c201404300313
_dVLOAD
_y201402041343
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aR-RZ
100 1 _aGauch, Ronald R.
_eautor
_9310757
245 1 0 _aIt's Great! Oops, No It Isn't :
_bWhy Clinical Research Can't Guarantee the Right Medical Answers /
_cby Ronald R. Gauch.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2009.
300 _brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
500 _aSpringer eBooks
505 0 _aMedical Research Explained -- Medical Research – Searching for Answers -- The Case-Control Method – Looking Backwards -- The Cohort Study – Watchful Waiting -- The Clinical Trial –The Gold Standard -- Comparing the Methods – Qualitative Differences -- Understanding the Clinical Trial -- The Protocol – The Guiding Light -- The Control Group – Leveling the Playing Field -- Measurements – They'ever Exact -- Bias Control – A Closer Look at Blinding and Randomization -- Utility – Are Clinical Trial Results Useful? -- Research Discrimination – Inadequately Tested Populations -- Seven Deadly Flaws – The Clinical Trials' Achilles' Heel -- Tools of the Trade -- Statistics – Was the Finding Significant? -- Analysis Issues – A Lot of Choices -- Meta Analysis – An Alternative to Large Trials -- The Real World -- Research Results That Clashed – What's the Right Answer? -- Hormone Replacement Therapy – The Silver Bullet That Misfired -- Publishing – Getting the Word Out to Doctors -- The Public Forum – Sharing the News with the Public -- Product Development – Getting Discoveries to the Market -- Medical Innovations – Regulators, Resources and Results -- Science and Politics – A Troubling Mixture -- Research Misconduct – Irresistible Temptation -- Postmarketing Surveillance – An Imperfect System -- Regulatory Reform – Changes Needed -- Journey's End – A Call for Action.
520 _aThis book dissects medical research methodology and through a penetrating inquiry into its triumphs and tragedies explains why correct answers are so hard to achieve. What emerges from this inquiry is the unexpected and stunning conclusion that medical researchers can never be sure that they’ve ended up with a truthful answer. In It’s Great! readers learn why the quest for knowledge through clinical trials is fraught with problems that even the best researchers cannot overcome. A fascinating gallery of cases illustrates the perils investigators face. Particular emphasis is given to the “clinical trial”, the so-called gold standard for medical research, and its seven fatal flaws show succinctly why getting the right research answer is so problematic. In example after example, the author challenges the notion that medical research is too complex for the average citizen to comprehend. Understanding the imperfect world of clinical research allows the reader to step up and begin to ask his or her own questions, to challenge conclusions, to have doubts and not be afraid to raise them. People who care about their health and the health of others should not be innocent bystanders; they have a right, maybe even an obligation to become involved. After all, it’s their health that is at stake.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781402089060
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-8907-7
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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