000			04766nam a22003855i 4500
001			283404
003			MX-SnUAN
005			20160429154233.0
007			cr nn 008mamaa
008			150903s2008 ne | o |||| 0|eng d
020			_a9781402082313 _99781402082313
024	7		_a10.1007/9781402082313 _2doi
035			_avtls000335905
039		9	_a201509030255 _bVLOAD _c201404300308 _dVLOAD _y201402041335 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC321-580
100	1		_aAsea, Alexzander A. A. _eeditor. _9308868
245	1	0	_aHeat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection / _cedited by Alexzander A.A. Asea, Ian R. Brown.
264		1	_aDordrecht : _bSpringer Netherlands, _c2008.
300			_axvI, 373 páginas _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aHeat Shock Proteins ; _v3
500			_aSpringer eBooks
505	0		_aHeat Shock Proteins and Neurodegenerative Diseases -- Chaperones and Polyglutamine Expansion Disorders -- Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease -- Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperones -- Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis -- The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases -- Neuroprotective Features Of Hsp90 Inhibitors Exhibiting Anti-Inflammatory Actions: Implications For Multiple Sclerosis -- Role of HspB1 and HspB8 in Hereditary Peripheral Neuropathies: Beyond the Chaperone Function -- Heat Shock Proteins and Neuroprotection -- Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection -- Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke -- Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons -- Use of Viral Gene Delivery Systems to Investigate the Neuroprotective Roles of Hsp70 and Hsp40 Proteins -- Heat Shock Proteins at the Synapse: Implications for Functional Protection of the Nervous System -- Extracellular Heat Shock Proteins and The Nervous System -- Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System -- Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extension in Neuroblastoma Cells -- Extracellular Chaperones and Amyloids -- Aging, Control Of Life Span and Expression Of Heat Shock Proteins -- Neural Expression Of Small Heat Shock Proteins Influences Longevity And Resistance To Oxidative Stress -- Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 and DAF-16 -- Protein Quality Control and Heat Shock Gene Expression in the Nervous System -- Serum Hsp70 Level as a Biomarker of Exceptional Longevity -- Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection.
520			_aWith the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis have been termed 'protein misfolding disorders' that are characterized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a therapeutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregation-prone proteins. This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. Key laboratories from major universities around the world contribute chapters that review present research activity and project the field into the future.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aBrown, Ian R. _eeditor. _9310895
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781402082306
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4020-8231-3 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942			_c14
999			_c283404 _d283404