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008			150903s2009 xxu| o |||| 0|eng d
020			_a9781441903228 _99781441903228
024	7		_a10.1007/9781441903228 _2doi
035			_avtls000337968
039		9	_a201509030254 _bVLOAD _c201404300338 _dVLOAD _y201402060858 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aR-RZ
100	1		_aPasterkamp, R. Jeroen. _eeditor. _9314597
245	1	0	_aDevelopment and Engineering of Dopamine Neurons / _cedited by R. Jeroen Pasterkamp, Marten P. Smidt, J. Peter H. Burbach.
264		1	_aNew York, NY : _bSpringer New York, _c2009.
300			_brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v651
500			_aSpringer eBooks
505	0		_aDevelopment of the Dopamine Systems in Zebrafish -- Dopamine Systems in the Forebrain -- The Role of Otx Genes in Progenitor Domains of Ventral Midbrain -- Terminal Differentiation of Mesodiencephalic Dopaminergic Neurons: -- Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons -- Transcriptional Regulation of Their Survival: -- Neurotrophic Support of Midbrain Dopaminergic Neurons -- TGF-? in Dopamine Neuron Development, Maintenance and Neuroprotection -- Axon Guidance in the Dopamine System -- Protocols for Generating ES Cell-Derived Dopamine Neurons -- Molecular and Cellular Determinants for Generating ES-Cell Derived Dopamine Neurons for Cell Therapy.
520			_aThe neurotransmitter dopamine has just celebrated its 50th birthday. The discovery of dopamine as a neuronal entity in the late 1950’s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransmitter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbrain dopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and their projections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization of Nurr1 and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins that have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminal differentiation and finally maintenance of the mdDA neuronal pool. In addition, work showing that the historically distinguished regions of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA ) harbor molecularly distinct sets of neuronal groups with specific connectivity patterns has added a new layer of complexity to how mdDA neurons are generated and function in the adult CNS. The current challenge in the field of dopamine research is to characterize the full extent of molecular processes that underlie mdDA neuron programming and to translate these findings into viable approaches for embryonic stem (ES)-cell engineering as an ultimate treatment of degenerative diseases as Parkinson’s disease. The chapters presented in this book provide an overview of the different stages that are distinguished during mdDA neuronal development. Chapter 1 discusses the dopamine systems of the zebrafish, being a powerful model organism for genetic intervention on the developmental programming of neuronal systems. In Chapter 2 an overview is presented of dopamine systems that are present in the vertebrate CNS. Chapters 3-6 discuss the early specification of dopamine precursors and the programs that lead to terminal differentiation. In Chapters 7 and 8 the maintenance of dopamine neurons is discussed with a special emphasis on neurotrophic support. The specific connectivity of the dopamine system and the axon guidance rules that apply to developing dopamine neurons are described in Chapter 9. An overview of ES-cell engineering of dopamine neurons is presented in Chapters 10 and 11. The research directed towards unraveling the molecular programming of mdDA neurons continues to be highly exciting. One may expect that novel biological principles will continue to emerge from this population of neurons. In the near future the field as a whole will mature towards a more comprehensive understanding of mdDA neuronal development and network integration, and will continue to apply knowledge of dopamine neuron development and function to the treatment of human disease.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aSmidt, Marten P. _eeditor. _9314598
700	1		_aBurbach, J. Peter H. _eeditor. _9314599
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781441903211
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4419-0322-8 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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