000			03321nam a22003855i 4500
001			286201
003			MX-SnUAN
005			20160429154448.0
007			cr nn 008mamaa
008			150903s2010 xxu| o |||| 0|eng d
020			_a9781441963277 _99781441963277
024	7		_a10.1007/9781441963277 _2doi
035			_avtls000338632
039		9	_a201509030326 _bVLOAD _c201404300348 _dVLOAD _y201402060915 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aR-RZ
100	1		_aAnderluh, Gregor. _eeditor. _9314731
245	1	0	_aProteins Membrane Binding and Pore Formation / _cedited by Gregor Anderluh, Jeremy Lakey.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_axviii, 150 páginas 46 ilustraciones, 3 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v677
500			_aSpringer eBooks
505	0		_aEnergetics of Peptide and Protein Binding to Lipid Membranes -- Membrane Association and Pore Formation by Alpha-Helical Peptides -- Role of Membrane Lipids for the Activity of Pore Forming Peptides and Proteins -- Cholesterol-Dependent Cytolysins -- Laetiporus sulphureus Lectin and Aerolysin Protein Family -- Interfacial Interactions of Pore-Forming Colicins -- Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins -- Molecular Mechanism of Sphingomyelin-Specific Membrane Binding and Pore Formation by Actinoporins -- Hemolysin E (HlyE, ClyA, SheA) and Related Toxins -- Pore formation by Cry toxins -- Role of Heparan Sulfates and Glycosphingolipids in the Pore Formation of Basic Polypeptides of Cobra Cardiotoxin -- Amyloid Peptide Pores and the Beta Sheet Conformation.
520			_aThere are currently only two structures of pores available, of ?-toxin from Staphylococcus aureus and hemolysin E from Escherichia coli. So what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane binding and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aLakey, Jeremy. _eeditor. _9314732
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781441963260
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4419-6327-7 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c286201 _d286201