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001			287199
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007			cr nn 008mamaa
008			150903s2013 xxk| o |||| 0|eng d
020			_a9781447143000 _99781447143000
024	7		_a10.1007/9781447143000 _2doi
035			_avtls000339778
039		9	_a201509030840 _bVLOAD _c201404300405 _dVLOAD _y201402060943 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC927-927.5
100	1		_aEbringer, Alan. _eautor _9307335
245	1	0	_aAnkylosing spondylitis and Klebsiella / _cby Alan Ebringer.
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c2013.
300			_axx, 256 páginas 89 ilustraciones, 86 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
500			_aSpringer eBooks
505	0		_aAnkylosing spondylitis as a scientific problem -- History of the origin of ankylosing spondylitis -- The discovery of HLA-B27 in ankylosing spondylitis and related disorders -- Molecular mimicry between  HLA-B27 and Klebsiella bacteria investigated by using rabbit antisera -- Molecular mimicry between HLA-B27 and Klebsiella bacteria investigated by using human tissue typing sera -- Muscle changes in ankylosing spondylitis -- Raised serum IgA is present in ankylosing spondylitis patients -- Faecal cultures in ankylosing spondylitis and uveitis -- Biochemical parameters and Klebsiella in ankylosing spondylitis -- Binding of Klebsiella antisera to HLA-B27 cells -- IgA antibodies to Klebsiella  and other Gram-negative bacteria in ankylosing spondylitis -- IgA antibodies to Klebsiella  measured by immunoblotting -- Antibodies to Klebsiella in ankylosing spondylitis measured by bacterial agglutination and ELISA against lipopolysaccharides -- Dutch and German patients with ankylosing  spondylitis have antibodies to Klebsiella -- Spanish, Finnish and Swedish patients with ankylosing  spondylitis have antibodies to Klebsiella -- Molecular mimicry between Klebsiella pullulanase enzyme, HLA-B27 and collagens I and IV -- Antibodies to Klebsiella and HLA-B27 peptides in ankylosing spondylitis patients from southern Japan -- Ankylosing spondylitis sera are cytotoxic to cells bearing HLA-B27 sequences -- Pathogenesis of ankylosing spondylitis and Klebsiella substrates -- Ankylosing spondylitis and the “low starch  diet” -- The problem of Crohn’s disease and Klebsiella -- Ankylosing spondylitis and “Popper sequences”.
520			_aAnkylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria.   When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts.  This is the concept of molecular similarity or “molecular mimicry” which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis.   The first paper on this subject was published in 1976 and since then over 100 papers on rheumatological topics have been published, from Prof Ebringer’s group, at the Division of Life Sciences, King’s College in London, UK.   The relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781447142997
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4471-4300-0 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c287199 _d287199