000			02717nam a22003855i 4500
001			287293
003			MX-SnUAN
005			20160429154541.0
007			cr nn 008mamaa
008			150903s2010 xxu| o |||| 0|eng d
020			_a9781441982315 _99781441982315
024	7		_a10.1007/9781441982315 _2doi
035			_avtls000339184
039		9	_a201509030314 _bVLOAD _c201404300356 _dVLOAD _y201402060929 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRC261-271
100	1		_aAyed, Ayeda. _eautor _9316403
245	1	0	_ap53 / _cby Ayeda Ayed, Theodore Hupp.
264		1	_aBoston, MA : _bSpringer US : _bImprint: Springer, _c2010.
300			_axvI, 200 páginas 59 ilustraciones, 3 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aMolecular Biology Intelligence Unit, _x1431-0414 ; _v1
500			_aSpringer eBooks
505	0		_aTP53 Mutations in Human Cancers: Selection versus Mutagenesis -- Lessons on p53 from Mouse Models -- TP63, TP73: The Guardian’s Elder Brothers -- The Regulation of p53 Protein Function by Phosphorylation -- The p53-Mdm2 Loop: A Critical Juncture of Stress Response -- Cooperation between MDM2 and MDMX in the Regulation of p53 -- Regulation and Function of the Original p53- Inducible p21 Gene -- p53 Localization -- Modes of p53 Interactions with DNA in the Chromatin Context -- p53’s Dilemma in Transcription: Analysis by Microarrays -- Tumor Viruses and p53 -- p53 and Immunity.
520			_aThis volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical genetics have identified and studied mutations in p53 found in human cancers, how p53 can be regulated by post-translational modification, and how key drug targets have been defined, namely MDM2, which has provided fundamental approaches for defining how p53 can be activated with potentially therapeutic effect. The key concepts in the chapters included provide a perspective on key paradigms in the p53 field.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aHupp, Theodore. _eautor _9316404
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781441982308
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4419-8231-5 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
942			_c14
999			_c287293 _d287293