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001			287976
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008			150903s2013 xxu| o |||| 0|eng d
020			_a9781461451075 _99781461451075
024	7		_a10.1007/9781461451075 _2doi
035			_avtls000341520
039		9	_a201509030329 _bVLOAD _c201405050230 _dVLOAD _y201402061101 _zstaff
040			_aMX-SnUAN _bspa _cMX-SnUAN _erda
050		4	_aRB155-155.8
100	1		_aChan, Edward K. L. _eeditor. _9317482
245	1	0	_aTen Years of Progress in GW/P Body Research / _cedited by Edward K. L. Chan, Marvin J. Fritzler.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_axI, 276 páginas 47 ilustraciones, 25 ilustraciones en color. _brecurso en línea.
336			_atexto _btxt _2rdacontent
337			_acomputadora _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_aarchivo de texto _bPDF _2rda
490	0		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v768
500			_aSpringer eBooks
505	0		_aPreface -- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su antigen) -- GW/P Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-mediated Gene Silencing -- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities -- Deadenylation and P-bodies -- Relationship of GW/P-bodies with Stress Granules -- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies -- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research -- Index.
520			_aGW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.
590			_aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700	1		_aFritzler, Marvin J. _eeditor. _9317483
710	2		_aSpringerLink (Servicio en línea) _9299170
776	0	8	_iEdición impresa: _z9781461451068
856	4	0	_uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-5107-5 _zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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999			_c287976 _d287976