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001 287992
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008 150903s2013 xxu| o |||| 0|eng d
020 _a9781461459309
_99781461459309
024 7 _a10.1007/9781461459309
_2doi
035 _avtls000341771
039 9 _a201509030339
_bVLOAD
_c201405050233
_dVLOAD
_y201402061107
_zstaff
040 _aMX-SnUAN
_bspa
_cMX-SnUAN
_erda
050 4 _aRB112.5
100 1 _aJugdutt, Bodh I.
_eeditor.
_9317498
245 1 0 _aCardiac Remodeling :
_bMolecular Mechanisms /
_cedited by Bodh I. Jugdutt, Naranjan S. Dhalla.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _axI, 569 páginas 80 ilustraciones, 48 ilustraciones en color.
_brecurso en línea.
336 _atexto
_btxt
_2rdacontent
337 _acomputadora
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
_2rda
490 0 _aAdvances in Biochemistry in Health and Disease ;
_v5
500 _aSpringer eBooks
505 0 _aPart I: Molecular mechanisms of remodeling in pressure and volume overload hypertrophy and ehart failure -- ?-adrenergic receptor signaling pathway in heart failure -- Remodeling of potassium channels in cardiac hypertrophy -- Role of gender in Ca2+ cycling and cardiac remodeling due to heart failure -- The failing heart: is it an inefficient engine or an engine out of fuel? -- Regulation of cardiac hypertrophic remodeling by the USP15/SLIM1 pathway -- Role of galectin-3 pathways in the pathogenesis of cardiac remodeling and heart failure -- A mitochondriocentric pathway to cardiomyocyte necrosis:  an upstream molecular mechanism in myocardial fibrosis -- The ACE2/Ang (1-7) pathway in cardiac remodeling due to pressure-overload -- Local actions of natriuretic peptides and nitric oxide in cardiac remodelling: Implications for therapy -- Modulating G protein-coupled receptors to effect reverse cardiac remodeling -- Role of inflammation and matrix proteinases in cardiac remodeling following stress and injury -- Role of chymase in matrix and myocardial remodeling due to mitral regurgitation. Implications for therapy -- Cardiac remodeling due to aortic regurgitation and mitral regurgitation -- Reducing oxidative stress and manipulating molecular signaling events using resveratrol as a therapy for pathological cardiac hypertrophy -- Angiogenesis, arteriogenesis, and mitochondrial dysfunction -- Part II: Molecular mechanisms of remodeling after myocardial injury and infarction -- Subcellular remodeling and cardiac dysfunction due to ischemia-reperfusion injury -- Role of microRNAs in cardiac hypertrophy and post-infarction remodeling -- Negative regulators of inflammation as endogenous protective mechanisms in post-infarction remodeling -- TLR-dependent pathways and Akt/mTOR/P70S6K pathways in cardiac remodeling after myocardial infarction -- The STAT3 pathway and downstream mechanisms in cardiac remodeling: Friend or foe -- The role of growth differentiation factor 5 in cardiac repair post myocardial infarction -- Extracellular matrix biomarkers of adverse remodeling after myocardial infarction -- Oxidative stress in cardiac repair and remodeling: Molecular pathways and therapeutic strategies -- Role of SPARC in cardiac extracellular matrix remodeling after myocardial infarction -- Tissue inhibitor of matrix metalloproteinases in the pathogenesis of heart failure syndromes -- Intracellular matrix remodeling and cardiac function in ischemia-reperfusion injury -- Aging and markers of adverse remodeling after myocardial infarction -- Optimizing stem cell therapy for cardiac repair following a myocardial infarction -- Regulation of fibrosis after myocardial infarction. Implications for ventricular remodeling -- The ACE2/Ang-(1-7) pathway in cardiac fibroblasts as a potential target for cardiac remodeling.
520 _aThe main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
590 _aPara consulta fuera de la UANL se requiere clave de acceso remoto.
700 1 _aDhalla, Naranjan S.
_eeditor.
_9312960
710 2 _aSpringerLink (Servicio en línea)
_9299170
776 0 8 _iEdición impresa:
_z9781461459293
856 4 0 _uhttp://remoto.dgb.uanl.mx/login?url=http://dx.doi.org/10.1007/978-1-4614-5930-9
_zConectar a Springer E-Books (Para consulta externa se requiere previa autentificación en Biblioteca Digital UANL)
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